Studies on chlamydia pneumoniae, strain TWAR, infection. 2. Seroepidemiology of TWAR on healthy controls and patients with acute respiratory infections.:Seroepidemiology of TWAR on Healthy Controls and Patients with Acute Respiratory Infections
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To determine of Chlamydia pneumoniae, TWAR infection is common in Japan. The author performed a spot antibody prevalence study of adults and children living in Okayama prefecture. This study was carried out by microplate immunofluorescence antibody tchnique (MFA) using in situ inclusions of <I>Chlamydia pneumoniae</I> (TW-183), <I>Chlamydia trachomatis</I> (L<SUB>2</SUB>) and Chlamydia psittaci (Cal 10) as antigens respectively. And each chlamydial antiserum IgG, IgA, IgM titers were determined by the dilution and point for specific staining of the inclusions. The author studied people with and without evidence of acute respiratory infections, as determined by physical examination and medical history.<BR>2050 sera of 1477 cases were collected from both groups between 1987 and 1989. The criteria for judgement the positivity of antibodies to chlamydia species are as follows: By comparing the IgG antibody titers determined with different chlamydia antigen, a case was regarded as having an antibody specific to a paticular chlamydia species when the titer was hightest for that strain and the titer was greater than ×64. In cases which blood was collected more than once, the point in time at which IgG showed the highest titer was used.<BR>TWAR specific antibody was detected to be 52/143 cases (36.4%) of healthy children (age 0-15) and 319/531 cases (60.1%) of healthy adults (age 16-85). It was also detected to be 134/478 cases (27.9%) of child patients with acute respiratory infections (age 0-15), and 231/325 cases (71.1%) of adult patients (age 16-95). In adult patient group, the rate of carrying the TWAR specific antibodies was significantly higher (p<0.01), and also high titer IgG (×512≤) and IgA (×128≤) were significantly higher (p<0.001) than thiese in control group. As for differences between sexes in carrying of the TWAR specific antibody, no significant difference was noted between two groups in children and adults. Primary seroconversion was observed at around age 6 and then rapidly increased in number (more than 60%) up to age 15. From the results, it is likely that <I>Chlamydia pneumoniae</I> is very commonly prevalent and plays a role as one of the pathogens of acute respiratory infections in Japan as well.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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