Effects of macrolide antibiotics against mucoid Pseudomonas aeruginosa.
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概要
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Macrolide antibiotics at concentrations by far lower than their MICs proved to inhibit the production of alginate, elastase and protease by mucoid <I>Pseudomonas aeruginosa</I>. The morphological study of mucoid <I>P. aeruginosa</I> under the electron microscope revealed the slime-like structures common to the cell morphology of the organism in cultured colonies and foci in a model for respiratory tract infection in mice, and the strains of mucoid <I>P. aeruginosa</I> which had been allowed to get in contact with the drugs proved to produced obviously fewer slime-like structures than control strains. The effect of a 14-membered macrolide, erythromycin, against mucoid <I>P. aeruginosa</I> was also observed with a 16-membered macrolide, rokitamycin this effect appeared to be common to the macrolide.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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