Protective effects of Mycoplasma pneumoniae live vaccine or its hyperimmune serum on the experimental infection in mice.
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概要
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SPF-BALB/c mice in which <I>Mycoplasma pneumoniae</I> cell proliferation accompanied by immunological responses had beenconfirmed, were immunized with live vaccines or with hyperimmune sera of <I>M. pneumoniae</I> FH-P24 and its mutant strains (P24-S1, P24-S11), were then assayed for infection-protection.<BR>Eight weeks after the last vaccination, 70 percent protection was obtained by inoculation once or twice with live FH-P24 and P24-S1 vaccines, respectively. After 12 weeks, 80% protection was achieved by FH-P24 and 60% by P24-S 1 live vaccine, while protectivity was not obtained by P24-S11 live vaccine.<BR>In case of passively immunized mice, IgG antibody titers and protective effect were not always found to be parallel. Namely, mice which were passively immunized with anti-FH-P24 serum, showed only 20% protection. However to get the above results, it was necessary that the anti-mutant strain serum be ten times higher than anti-FH-P24 serum in IgG titer.<BR>In the immunoblot anslysis, sera from patients infected with <I>M. pneunoniae</I> immunoblotted the 168-KDa (P1 protein) and the 85-KDa protein of FH-P24 and P24-S1, but not the 85-KDa protein of P24-S11.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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