Infectious disease by drug resistant staphylococcus aureus and their susceptibility to antimicrobial agents.
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概要
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An investigation was made on the frequency of isolation and susceptibility to antibiotics and the effect of chemotherapy, with drug resistant <I>Staphylococcus aureus</I> which are derived from β-lactamase by plasmidal DNA and by the change of PBP regulated by chromosomal DNA, and the following results were obtained:<BR>1) The mean isolated frequency of β-lactamase producing <I>S. aureus</I> from 1982 to 1985 was 63.6%, and that of methicillin resistant <I>S. aureus</I> (MRSA) was 14.1% respectively.<BR>2) The isolated frequency of β-lactamase producing <I>S. aureus</I> was not so variable among clinical specimens, however, those of MRSA were high in blood, catheter tips, and pus.<BR>3) The results of susceptibility of MRSA to antibiotics were excellent in MCIPC, OFLX, VCM, followed by MINO, GM, AMK, FOM, IPM/CS, FMOX. The effect of temperature on susceptibility was remarkable at 30°C which is the most satisfactory temperature for the appearance of PBP-2', and at that temperature the effect of β-lactamase to the susceptibility was almost not noted.<BR>4) The excellent clinical effects of chemotherapy by viccillin-S (ABPC/MCIPC) in 2 cases of sepsis and MINO was effective in 1 case of pneumonia.<BR>As a result of this study, the strict temperature of culture at 30°C is necessary for the detection of MRSA, and for clinical success of chemotherapy.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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