Experimental Salmonellosis in Cynomolgus Monkey:II. Observations of Bacillary Invasion and Mucous Antibody by Immunofluorescence Method
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Fourteen cynomolgus monekys, weighed 2-4 Kg, were orally given salmonella typhimurium or salmonella enteritidis (3-5×10<SUP>7-8</SUP>/ml cell) after fasting for two days. CaCO<SUP>3</SUP> of 500mg was also given immediately before the bacillary administration. Clinical course, histopathological findings of the intestine, bacillary invasion and its habitation in the intestine and other organs, and mucous antibodies in the intestinal mucous tissue, spleen and lymphglands were investigated using immunofluorescence method among others. Although two salmonella species were used in this experiment, any mentionable difference couldn't be found in the results between the two and, thus, a general summarization was drawn as follows:<BR>1) The onset of the illness was 48-72 hours after the bacillary administration in general.<BR>2) Twenty four hours after the onset of the illness, salmonella bacilli were seen invading into the small intestine, the cecum, and the rectum.<BR>3) By 48 hours after the onset of the illness, the bacillary invasion into the small intestine was seen quantitatively decreasing and around 72 hours after the onset of the illness the bacillary growth in the cecum and the rectum became the greatest. If the animals survived the crucial 96 hours after the onset of the illness, they improved gradually, and after one week bacillary invasion couldn't be observed any more. However, in only one case which got into carrier state, a large quantity of the bacilli was found invading and habitating in the cecum, the rectum and lymphglands even after 2 weeks after the onset of the illness.<BR>4) During acute stage, bacillary invasion could be seen in the lymphglands, the spleen and the gall bladder.<BR>5) In the intstinal mucous membrane, IgA found in lamina propria became secretory IgA in coincidence with bacillary invasion. IgM and IgG are principally found in Lamina propria, but it appeared in this experiment that IgM is sometimes secreted. Impression is that IgA is most closely related with the phase of the bacillary invasion.<BR>6) In the lymphnodes and spleen, IgM appeared first and most prosperous coincided with acute stage of bacillary invasion. IgG appeared a little while later. One carrier state monkey investigated had shown no IgM producing cell in the lymphnodes and spleen.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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