Model-Based Study on Activeness of Neuronal Dendrites and Its Functional Significance.
スポンサーリンク
概要
- 論文の詳細を見る
Recent neurophysiological experiments showed that neuronal dendrites could be recognized as active systems rather than passive transmission lines due to the existence of varied types of voltage-gated ionic channels. This study is performed to clarify functional significance of such an active propery of neuronal dendrites. In order to achieve this, a compartment neuron model is constructed so that the model closely mimicks the most recently found responsiveness of neurons with active dendrites. Based on the model, generation and propagation of action potentials and the associated behavior of intracellular Ca2+ concentration are simulated for various combinations of synaptic inputs. Inhibitory synaptic inputs are found to control the propagating dendritic area of the action potentials. Since the propagation of the action potential is accompanied by an increase of intracellular Ca2+ concentration, the inhibitory input could shape synaptic organizations on the dendritic tree through the well-known Ca2+-induced synaptic plastihity. In addition, an action potential generation in the soma is shown to differentiate levels of the interacellular Ca2+ concentration in the whole dendritic area. Finally, we reach the hypothesis that the activeness of the dendritic system could serve to broadcast the information concerning somatic firing to the whole dendritic tree, which is mediated by the associated increase of the intracellular Ca2+ concentration.
- 一般社団法人 日本生体医工学会の論文
一般社団法人 日本生体医工学会 | 論文
- Evaluating the Workload Reduction of Automatic Vital Data Transmission
- Mental Fatigue Measurement Based on the Changes in Flicker Perception Threshold using Consumer Mobile Devices
- A Theoretical Study on a Computational Algorithm for Human Posture Estimation Based on Motion Capture of a Small Number of Markers
- Latest microscopic technique. From the principle to application. Development of three-dimensional microscopic system for operation of mini-pig fertilized eggs.
- A Study of the Automation of Cytodiagnosis (The Second Report):Cytophotometry Using Photomicroscanner and a Trial of Data-processing