Blood Coagulability and Fibrinolysis in Streptozotocin-induced Diabetic Rats
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Changes in coagulation and fibrinolysis in the plasma (<I>in vivo</I>) and hepatocytes (<I>ex vivo</I>) were studied using hyperglycemic rats. Hyperglycemia was induced by intravenous injection of 50 mg/kg streptozotocin (STZ). Eight weeks after the injection, we observed increases in thrombin-antithrombin III complex and tissue type plasminogen activator activity, decreases in plasma levels of antithrombin III, plasminogen and α<SUB>2</SUB>-plasmin inhibitor, and significant shortening of activated partial thromboplastin time. In freshly isolated or cultured hepatocytes from STZ-induced hyperglycemic rats, concentrations of proteins related to coagulation were increased. An increase in alanine-aminotransferase leakage and decreases in the levels of amylase, triglycerides and phospholipids were observed in the culture medium of hepatocytes from STZ-treated rats. <I>In vivo</I> study revealed that STZ-induced subchronic diabetes induced imbalance between coagulation and fibrinolysis, and <I>ex vivo</I> study in hepatocytes from STZ-treated rats showed membrane degeneration and reduction in amylase synthesis, while protein synthesis related to coagulation was not inhibited. These results suggest that, despite vulnerability of liver cells from STZ-treated rats, coagulation activity in the liver is retained and rather enhanced in STZ-induced hyperglycemic rats, which may contribute to the promotion of atherosclerosis. <I>J Atheroscler Thromb, 1997 ; 4 : 27-33.</I>
- 一般社団法人 日本動脈硬化学会の論文
一般社団法人 日本動脈硬化学会 | 論文
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