Correlation of DNA Copy Number Changes to Malignancy in Oral Squamous Cell Carcinomas by Comparative Genomic Hibridization.

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To compare clinical and histopathological findings to tumor DNA copy number changes, comparative genomic hybridization (CGH) was performed on 18 primary oral squamous cell carcinomas.<BR>Copy number increases were most frequently observed on 8q, 3q, 13q, lip, and llq, while copy number decreases most frequently on iOq, lp, 18q, 9p, and 19q.<BR>Copy number changes in relationship to WHO grading were examined with the result that DNA copy number increase on chromosome 6p23-25 was characteristically observed in the groups of Grade II and Grade III, and DNA copy number decreases on chromosomes 9p21 and llpll-13 were observed in the same groups. Furthermore, comparison of DNA copy number changes to TNM classification indicated that the decreases on chromosomes 1p36 and 10g25-26 might be related to tumor progression. Moreover, the relationship of DNA amplification or deletion to metastasis was investigated. It was found that the majority of the metastasis-positive tumors showed increases on 3g26 and 17g12-21 and showed decreases on chromosome 18g21.<BR>The data suggested that these DNA copy number changes on each chromosome in the three categories might be associated with tumor cell differentiation, tumor size, and lymph node metastasis.
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