Alterations of Hemostatic Markers in Cardioembolic Stroke

概要

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To assess the state of thrombosis and fibrinolysis, we measured the plasma concentrations of fibrinopeptide A (FPA), fibrinopeptide Bβ15-42 (FPBβ15-42), D-dimer, protein C (PC) activity and antigen, and antithrombin III (AT III) in 17 patients of cardioembolic stroke. Patient group had significantly high concentrations of FPA and FPBβ15-42, and significantly low concentrations of PC and AT III compared with healthy control group (p<0.005-0.05). D-dimer was increased in 5 of 7 patients, and both FPA and FPBβ15-42 were increased in 15 of 16 patients. In contrast, PC activity, PC antigen and AT III were reduced only in 6 of 12, 4 of 12 and 5 of 15 patients, respectively. These findings suggest that FPA, FPBβ15-42 and D-dimer may be useful to detect the activities of thrombosis and fibrinolysis in patients with cardioembolic stroke.
一般社団法人日本血栓止血学会の論文