Studies on the coagulation disorders and fibrinolysis in the experimental hepatectomy

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The hemorrhagic tendency after major hepatic resection is recognized to be related to the disorders of coagulation factors and the fibrinolytic phenomen.The regeneration of the liver after hepatic resection may promote to increase capacity of residual liver function as well as to improve the coagulation disorders and fibrinolysis.In this paper, we reported the comparative results of the coagulation disorders fibrinolysis after primary massive hepatic resection and secondery resection in dogs.In primary 70% hepatectomized group, the prologation of PT but not PTT were seen. The fibrinogen concentration and platelet counts were not decreased and GOT and Al-p recovered to the normal level soon.In primary 85% hepatectomized group, PT and PTT prolongations were remarkable in the first week after operation, but in secondary 85% hepatectomized group (50% residual liver resection, on six weeks after primary 70% hepatectomy). PT and PTT prolongation did not continued for 2 weeks.The level of GOT and Al-p in secondary group were much more elevated than in primary group and did not recover to the normar level in both group.Through these data, secondary hepatectomy might be less changed and safer than primary resection in the coagulation factors and hemorrhagic tendency after massine hepatic resection.
一般社団法人日本血栓止血学会の論文