Studies on hematopoietic stem cell:VII. In vitro growth of granuloid colony-forming cell in systemic lupus erythematosus
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Leukopenia is common in collagen disease, especially systemic lupus erythematosus (SLE). However, the pathogenesis of leukopenia in SLE has not as yet been resolved.In order to make clear granulopoiesis in SLE, the ability to grow in vitro granulocyte colonies (CFU-c) in 9 patients with SLE including a patient with progressive systemic sclerosis was studied using a semi-solid double agar culture method of Robinson et al. and compared to that of 12 normal controls.The number of colonies formed in vitro was variable in non-treated SLE. However, the number of colonies formed per plate seemed to increase in the proportion to the increase in marrow M/E ratio. In addition, a case with myeloid hyperplasia was able to generate normal levels of CFU-c indicating that leukopenia in SLE may be due to the abnormality of colony stimulating factor production or release.On the other hand, the number of CFU-c was markedly reduced in patients with SLE who were during treatment, suggesting that immunosuppressants may affect the growth of CFU-c even in culture.
- 一般社団法人 日本血栓止血学会の論文
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