Studies in the measurement of fibrinogen on haemostasis
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Fibrinogen is one of the important factors of the coagulation and haemostasis. We have investigated in several cases the method of measuring the plasma fibrinogen and 131I-labelled fibrinogen disappearance curve.The plasma fibrinogen was assayed by the following method; thrombin time, tyrosine, and immuno partigen.1) The normal range of the plasma fibrinogen was from 250 to 350mg/dl.2) Definite correlation was observed among these methods, thrombin time, tyrosine and immuno partigen.3) DM and malignant tumor showed the hyperfibrinogenemia, and liver disease showed the hypofibrinogenemia. However 131I-labelled fibrinogen half life, in all of them, was shortened.4) In some cases with liver cirrhosis that showed hypofibrinogenemia, 131I-labelled fibrinogen half life was prolonged remarkably and the plasma fibrinogen increased after the injection of heparin. We consider it very important to measure the plasma fibrinogen and 131I-labelled fibrinogen half life in order to pick up knowledge on the role of haemostatic blance on haemostasis.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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