Studies on coagulation and fibrinolysis abnormalities in liver diseases
スポンサーリンク
概要
- 論文の詳細を見る
Twenty parameters for coagulation, fibrinolysis and their inhibitors were studied in 79 patients with liver diseases, including 15 cases of acute hepatitis, 1 of fulminant hepatitis, 13 of chronic hepatitis, 41 of liver cirrhosis and 9 of primary liver cancer.In acute hepatitis; plasminogen, factor V, factor VII, antithrombin III (AT III) and α1 antitrypsin (α1AT) tended to be decreased. Serial thrombin time 30′(STT 30′) was prolonged in 60% of cases. Fibrinogen-fibrin degradation product (FDP) was within the normal range. In only one case paracoagulation test was positive.In fulminant hepatitis; platelet count, plasminogen, thrombotest, hepaplastintest, fibrinogen, AT III and α1AT were decreased. Prothrombin time (PT) and STT 30′ were prolonged. FDP was increased (40üg/ml). These results were highly suggestive of not only severe synthetic failure but also of disseminated intravascular coagulation (DIC).In liver cirrhosis; platelet count, thrombotest, hepaplastintest, plasminogen, fibrinogen, factor V, factor VII, AT III and α1AT tended to be decreased. Increase in FDP and in α2 macroglobulin was found in 31% and 37% respectively. STT 30′ was prolonged in 87%. Paracoagulation test was positive in 15%.In chronic hepatitis; almost all parameters showed a similar pattern as liver cirrhosis, however PT, thrombotest and hepaplastintest tended to give normal results.In primary liver cancer; plasminogen and AT III were decreased while α1AT was increased. STT 30′ was prolonged in 67% and FDP was increased in 33%.Partial thromboplastin time was almost normal in liver diseases.In severe cases, the coagulation analysis revealed the increase of FDP, prolongation of STT 30′ and decrease of platelet count, AT III, plasminogen and coagulation factors except factor VIII (F. VIII) activity. As these findings were consistent with DIC, diagnosis of DIC in patients with liver diseases, especially liver cirrhosis should be made more carefully.Increase of F. VIII activity and F. VIII-related antigen, and decrease of F. VIII activity/F. VIII-related antigen ratio were obsereved in liver diseases, suggesting production-consumption imbalance of F. VIII. Measurement of F. VIII activity and F. VIII-related antigen might be helpful in diagnosis of DIC in patients with liver diseases.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
- 日本人のＡＤＡＭＴＳ１３
- Infection of specific strains of Streptococcus mutans exacerbated intracerebral hemorrhage
- Transcriptional regulation of megakaryopoiesis and thrombopoiesis
- 新規血小板活性化受容体ＣＬＥＣ－２ その発見から今後の展望まで:その発見から今後の展望まで
- １．臨床血栓止血学オーバービュー