Haemostatic studies in hepatitis
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概要
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We have often experienced the haemorrhagic diathesis in liver diseases.We have now investigated the haemostasis in hepatitis and liver cirrhosis, especially about the fibrinogen and the platelet.Then results are as follows.1) In active stage of acute hapatitis and in liver cirrhosis, PT prolonged, but PTT showed little change.2) The plasma fibrinogen increased in active stage of acute hepatitis, but decreased in chronic hepatitis and liver cirrhosis.3) Fibrinolytic activity increased, while AT-III decreased.4) In chronic hepatitis platelet count and platelet aggregation decreased, and negative correlation was recognized between platelet aggregation and γ-globulin.5) The enargement of platelet volume measured by Coulter counter was found in liver diseases, and it related to the change of haemorrhagic diathesis in some cases.6) 131 I-labelled fibrinogen half life shortened in hepatitis, especially in liver cirrhosis. And in several cases we recognized the prolongation of fibrinogen half after the injection of heparin.From the results of our investigation in liver diseases, our conclusion is that the thrombotic tendency and the intravascular coagulation are closely related to the progress of hepatitis.
- 一般社団法人 日本血栓止血学会の論文
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