Plasma factor XIII in normal children, in various disorders, and in the rabbits with lauric acid-induced thrombocytopenia
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Plasma factor XIII of babies and children were surveyed to determine normal range in each growth stage and the variation in several diseases were observed.To investigate the susceptibility of factor XIII by the effect of intravascular accident, thrombosis for instance, the experiment of laurtc acid-induced intravascular disorders with rabbits was carried out. The results were as follows.1) Concentration of factor XIII in cord blood was extremely low (7.7±2.6).2) In normal case, the level of factor XIII was the lowest (9.9±2.6) in new born baby, going up to the highest (22.0±5.6) in infancy, then slowly down to 18.0±7.7 in pre-school age, and 13.2+5.3 in school age.3) Plasma factor XIII was relatively increased in respiratory infections especially in streptococcosis, and was greatly varied from abnormally low to very high value in MCLS and ITP.4) Lauric acid was intrvenouly injected into rabbits according to Zbinden's experiment. By this effect plasma factor XIII was gradually decreased, while platelet count and fibrinogen level were pronouncedly altered.
- 一般社団法人 日本血栓止血学会の論文
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