Study of blood coagulatoin on chronic arterial obstructive disease
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概要
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Thromboangiitis obliterans (TAO) was introduced by Leo Buerger as an isolated desease of chronic arterial obstructive desease (1908).Recently, some investigators claimed that the desease bydesclibed Buerger is indistinguishable from arteri-osclirosis obliterans (ASO) or other peripheral arterial thrombosis. However, It is a fact that most cases are due to idiopathic peripheral arterial thrombosis, and it s certain etiology and pathogeneris are unknown. Present study is performed to investigate into changes of blood coagulation on TAO and ASO.Clinical materials and methodsBlood coagulability was studied on 12 cases of TAO, 10 cases of ASO, 12 normal persons as control.Blood samples were obtained by venous puncture to carry out blood test with respect to RBC, Ht., platelet count, bleeding time, prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen level and FDP. Platelet adhesive rate was examined by modified method of Hellem II.Results and discussionThere were no increase in RBC, Ht., platelet count, bleeding time, PT and PTT. Fibrinogen level was slightly increased on TAO. Platelet adhesive rate was increased on TAO. There were no relation between increased platelet adhesive rate and fibrinogen level. It is indicated that TAO is primarily a desease of the blood vessels rather than of the blood itself. However, increased platelet adhesive rate may be an important factor of secondary thrombus formation in this desease. FDP was increased in two of twelve cases of TAO and three of ten cases of ASO. Platelet adhesive rate markedly increased on TAO and ASO except the cases which FDP was increased. Therefore, it is necessary to consider FDP level when platelet adhesive rate is examined.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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