Studies on urinary urokinase, .ALPHA.2-plasmim inhibitor (TD-80), .ALPHA.2PI-plasmin-complex (TD-80C) and D-dimer during normal pregnancy, labor and puerperium.
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In a previous study, we reported that levels of Blood FPA were significantly increased since the second trimester, and that of blood Bβ15-42 was significantly increased since the first trimester till the full term pregnancy. Levels of urinary FPA/CRE and Bβ15-42/CRE were found to have the same pattern as blood FPA and Bβ15-42.These results suggested that blood FPA and Bβ15-42 were rapidly cleared into urine by glomerular filtration and hypermetabolism in the proximal tubule of the kidney. (Blood & Vessel, 19: 68-76, 1988.)In this study, urinary levels of UK/CRE, α2-PI/CRE, α2PI-Pm-C/CRE and D-dimer were persuaded during preg., Labor and puerperium as follows.1) UK/CRE was depressed whereas α2PI/CRE was increased markedly and α2PI-Pm-C/CRE slightly increased in 4-7 gestaional weeks.2) UK/CRE and α2PI-Pm-C/CRE were increased slightly and α2PI/CRE decreased slightly from 8-11 weeks to 16-19 weeks.3) UK/CRE, α2PI/CRE and α2PI-Pm-C/CRE were increased slightly and/or markedly from 20-23 weeks to 28-31 weeks, coming up to their peaks in 24-27 weeks.4) UK/CRE was deep-depressed whereas α2PI-Pm-C/CRE was markedly increased in 32-35 weeks.5) UK/CRE and α2PI-Pm-C/CRE were markedly increased but α2PI/CRE remained in the full them.6) On the other hand, blood α2PI-Pm-C was markedly increased in the first trimester, but it gradually decreased from mid-term until the full term.For these findings, it was suggested that the high levels of urinary α2PI-Pm-C/CRE during preg., labor and puerperium was attributed to rapid clearance blood through in tubule glomenular selective filtration and of matabolism.
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