Effect of OP-41483, a derivative of prostaglandin I2 on small caliber arterial reconstructive surgery.
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Canine femoral artery was substituted with expanded polytetrafluoroethylene graft (Gore-Tex) (inner diameter, 3mm) and the effect of OP-41483 α-CD (OP-41483) on the graft patency was studied at six weeks after the surgery. OP-41483 was intravenously infused at the dose of 20ng/kg/min for 3 hours two times a day. The period of administration was two weeks.In the control group (five animals) without drug treatment, the graft patency was 40%, while all grafts were patent in the OP-41483 treated group (four animals).The inhibitory effect of OP-41483 on platelet aggregation induced by ADP (5μM) was not observed ex vivo at the dose of 20ng/kg/min. But, the histological and electron scanning microscopic findings of the grafts showed that OP-41483 at the same dose obviously inhibited the platelet adhesion and aggregation, and this inhibitory effect might lead to elevation of the graft patency.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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