Alteration of tissue thromboxane B2 and 6-keto prostaglandin F1.ALPHA. of the burned tissue and the effect of the drugs which affect on the arachidonate cascade.

概要

論文の詳細を見る
The third degree burn covering 35% of the total body surface area was made on the back of rabbits, and the animal were divided into 6 groups. The effectiveness of infusion therapy, and some drugs which affect on arachidonate cascade (aspirin, OKY-046, CV-4151 and ONO-3708) after burn injury were studied by examining the changes of arachidonate cascade of the burned tissues. Determinations of tissue thromboxane B2 (TX) and tissue 6-keto prostaglandin F1α (PG) showed the increase of tissue TX in infusion therapy groups. On the contrary, tissue TX levels were decreased in ASA, OKY-046 and CV-4151 groups compared to infusion therapy group. Tissue PG levels decreased only in ASA group. On the other hand, tissue TX/PG ratio was decreased in OKY-046 and CV-4151 groups. Examination of wet-dry weight of the burned tissue revealed that only ASA decreased the amount of edema formation after burn injury while other drugs did not affect the increase of wet weight. It is suspected that the changes on arachidonate cascade at burned wound may play a role in edema formation, eventually affect the permeability of vessels on burned tissue.
一般社団法人日本血栓止血学会の論文