Preventive effect of MK-733 on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in JW rabbits.
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The preventive effect of MK-733 (Simvastatin), a potent inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by 1% cholesterol feeding in rabbits was examined. MK-803 (Lovastatin) was used as a comparative drug. The cholesterol feeding remarkably increased the serum total-, VLDL- and LDL-cholesterol and phospholipids levels, and slightly increased the HDL-cholesterol ones. MK-733 was found to prevent dose-dependently the increase of serum cholsterol levels, 2, 263mg/dl (treated control), 95mg/dl (10mg/kg), 445mg/dl (5mg/kg) and 982mg/dl (2.5mg/kg) at 12 weeks later. MK-803 (5mg/kg) inhibited them to 1, 130mg/dl. MK-733 inhibited the increase of VLDL-and LDL-cholesterol levels, but slightly affected HDL-cholesterol ones. MK-733 inhibited the increase of serum phospholipids levels. MK-733 preveted the development of atherosclerosis on aortae.The preventive effect of MK-733 at 2.5mg/kg on hypercholesterolemia and atherosclerosis was thought to be equal to those of 5mg/kg of MK-803.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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