The changes of protein C in cases with cardiac valve replacement soon after oral warfarin therapy.
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The changes of protein C was studied in the patients with cardiac valve replacement at the beginning of warfarin therapy. Protein C and thrombotest were measured during a period from the first day to the eighth day postoperatively in the 15 cases under going cardiac valve replacement.Warfarin therapy was started on second postoperative day in initial dosis of 2.0±1.3mg per day. After then, warfarin was administered in dosis of 2-3mg per day continuously.According to the medication of warfarin, protein C and thrombotest decreased from 106.0±14.0% (control) to 68.5±14.7% (4 days postoperatively) and from 109.6±13.9% (control) to 39.4±19.8 (4 days postoperatively) respectively. There were three cases who had decreased protein C under 50% in 6 days postoperatively. Nevertheless thrombotest was decreased under 30% at the same time in these cases.These results suggest protein C is not decreased significantly by the medication of small dosis warfarin.
- 一般社団法人 日本血栓止血学会の論文
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