Interaction of influenza virus and platelets.
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The interacion between influenza virus and platelets was observed under a transmission electron microscope by mixing virus (PR-8 strain) with PRP of human or rabbits. The adsorption of the virus onto the surface of the platelet was immediately observed. Some of the viruses started to invade into the platelets and were seen in the open canalicular systems. After two minutes, the platelets deformed significantly, marked decreased number of the granules and vacularization were seen. After 5 minutes, the mass of platelet aggergates can be seen. In addition, 2ml of virus suspension was intravenously administered to rabbits to see coagulation and pathological changes. The platelet counts decreased singnficantly, fibrinogen level decreased only after 2 hours, but fibrin monomer test showed negative. The platelet thrombi were observed in pulmonary capillaries and splenic tissues.From the above results, it is suspected that platelet aggregation is partly responsible for the development of thrombocytopenia in the inital stage of viral infection.
- 一般社団法人 日本血栓止血学会の論文
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