The inhibitory effect of aspirin on collagen induced aggregation of rat platelets. The influence of plasma.:The influence of plasma
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We investigated the inhibitory effect of aspirin on collagen induced platelet aggregation using rat PRP (platelet rich plasma) and GFP (gel filtered platelet). In the case of PRP, low concentration of collagen induced aggregation was inhibited by aspirin but when collagen concentration was increased, aggregation was observed in spite of the presence of aspirin. On the contrary, in the case of GFP, collagen induced aggregation was always inhibited by aspirin regardless of the collagen concentration. But when rat plasma was added to GFP, the inhibitory effect of aspirin on collagen induced aggregation decreased in a plasma dose dependent manner. These studies suggest that plasma factor(s) are essential for the aspirin noninhibited aggregation which is induced by high concentration of collagen.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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