Plasma lipoproteins inactivate platelet-activating factor (PAF).
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Inactivation of platelet-activating factor (PAF) by plasma was demonstrated by comparing platelet aggregation induced by PAF solution, which had been preincubated with plasma, with that induced by the control PAF solution preincubated with buffer. Plasma inactivated PAF in a volume-dependent manner while preincubation of ADP or collagen with plasma did not affect the platelet aggregating activity of these agents. These facts imply that the effect of plasma is specific to PAF.The pretreatment of plasma with diiospropylfluorophosphate abolished the effect of plasma on PAF. Pretreatment of plasma with p-bromophenacyl bromide, an inhibitor of phospholipase A2, did not affect the action of plasma on PAF. Although phospholipase A2 has been shown to hydrolyze PAF in vitro, the evidence warrants independence of the inactivating process on this enzyme.Plasma PAF inactivating activity was found to be associated with total lipoproteins which had been separated by ultracentrifugation, while lipoprotein-deficient plasma was completely inactive. Further fractionation of plasma by gel permeation high-performance liquid chromatography disclosed that the activity is associated with low-density and high-density lipoproteins.
- 一般社団法人 日本血栓止血学会の論文
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