Endotoxemia and tissue thromboplastin activity in the bone marrow cells effects of fibronectin.
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概要
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1) I mmunodifusion test with goat anti-human fibronectin showed cross-reaction between plasma fibronectins of human and mouse. 2) By the immunoturbidimetric assay, standard curves of human and mouse fibronectins were quite linear, and fibronectin concentrations in mouse plasma could be determined up to 200μg/ml. 3) Fibronectin levels in mouse plasma slightly decreased 8 hours after i. p. injection of 50μg of S. typhimurium endotoxin, however, dose response was not good. 4) Shortening of clotting time of human plasma by the addition of phospholipid was inhibited by incubation of phospholipid with fibronectin. 5) By prior incubation of tissue thromboplastin (simplastin) with fibronectin, about 50 to 80% of the thromboplastin activity was inhibited. 6) Fibronectin also inhibited the thromboplastin activity of bone marrow cells from mouse given endotoxin. 7) Thromboplastin-induced lethality in mice was inhibited by prior incubation of thromboplastin with fibronectin.Fibronectin has been known to bind to ganglioside or phospholipid. Therefore, these results indicate that inhibitory effects of fibronectin on the thromboplastin activity is thought to be due to the binding of fibronectin to phospholipid portion of thromboplastin.
- 一般社団法人 日本血栓止血学会の論文
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