Growth-inhibitory effects of platelet-derived TGF-.BETA. on SV3T3 and Meth A cells.
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The effects of transforming growth factor-β (TGF-β) from human platelets on anchorage-dependent and -independent growth of normal rat kidney fibroblast (NRK), SV-transformed mouse fibroblast (SV 3T3) and methylcholanthren-induced mouse fibrosarcoma A (Meth A) were investigated. In the presence of epidermal growth factor (EGF), TGF-β stimulated anchorage-dependent and -independent growth of NRK, whereas the same growth factor inhibited the growth of SV 3T3 and Meth A.The mechanism of synergistic effect by TGF-β and EGF was then analysed with regard to the expression of EGF receptors by using 125I-labelled EGF. The binding sites for EGF in NRK were increased by treatment with TGF-β, but not in SV 3T3 and Meth A. On the other hand, intracellular turnover rate of EGF-EGF receptor complex in NRK was not affected by treatment with TGF-β, though it was significantly impaired by the same treatment in Meth A.
- 一般社団法人 日本血栓止血学会の論文
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