Combined effects of urinary plasminogen activator and tissue-type plasminogen activator in vitro and in vivo models.
スポンサーリンク
概要
- 論文の詳細を見る
The in vitro and in vivo combined effects of urinary plasminogen activator (u-PA) and tissue plasminogen activator (t-PA) were examined. In in vitro experiments the additive combined effects of u-PA and t-PA were observed on human plasma clot lysis. In in vivo studies using a canine coronary thrombus model, an intravenous combined administration of t-PA and u-PA synergistically enhanced their thrombolytic activity, while the reductions of fibrinogen, plasminogen and α2-plasmin inhibitor were additive.The studies on plasma and blood dynamic viscosities revealed that whole blood dynamic viscosity decreased significantly in both u-PA and the combination groups, while plasma viscosity was not changed. This lowered blood viscosity was rather notable at the lower shear rate condition than at the higher shear rate. It is, therefore, presumed that this combination therapy may have a great advantage on thrombolysis in acute myocardial infarction.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
- 日本人のＡＤＡＭＴＳ１３
- Infection of specific strains of Streptococcus mutans exacerbated intracerebral hemorrhage
- Transcriptional regulation of megakaryopoiesis and thrombopoiesis
- 新規血小板活性化受容体ＣＬＥＣ－２ その発見から今後の展望まで:その発見から今後の展望まで
- １．臨床血栓止血学オーバービュー