Adhesion of fibrinogen at high concentrations.
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概要
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Fibrin gels formed in the presence of thrombin have exhibited to be able to adhere plastics. This adhesion became a strong with increment of fibrinogen concentrations of the system, whereas changes in the thrombin concentrations gave a constant value. No significant effect of NaCl, CaCl2 on the fibrin adhesion was observed. However, the adhesion is if anything slightly stronger for a fine than for a coarse gel. In the presence of plasmin, the adhesive force of fibrin became a weak with the degradation of fibrin deposits, indicating that the amount of fibrin clots itself is play a role on the force of adhesion.An experiment of the fibrin adhesion during gelation process has showed that concomitant with increase in γ-chain cross-linking as judged by SDSPAGE analysis, there is increase in the adhesive force. During this process, no cross-linking of α-chain occurred. These results have suggested that the γ-chain cross-linking is also important to the fibrin adhesion. This has been also supported by the experiment using Batroxobin which induces γ-chain cross-linking alone.
- 一般社団法人 日本血栓止血学会の論文
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