Binding studies of anti-human platelet glycoprotein IIb/IIIa monoclonal antibodies to cultured vascular endothelial cells.
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The binding of anti-human platelet glycoprotein (GP) IIb/IIIa monocolonal antibodies to human umbilical vein endothelial cells (HUVE) was studied. Scatchard analysis using 125 I-anti-platelet GPIIb/IIIa monoconal antibody showed that the maximum binding capacity was 8×104/cell and Kd was 40.2nM. The binding rates of 125 I-anti-platelet GP IIb/IIIa monocolonal antibodies to HUVE treated with TTP sera and ITP sera were 11.6±2.8% and 15.2±3.3%, compared with the 24.0±7.5%, observed for HUVE treated with normal sera. A combination analysis of SDS-PAGE and western blotting of washed platelet and HUVE lysates showed that two proteins were similar or identical molecular masses.These findings showed that TTP sera and ITP sera may contain antiplatelet GP IIb/IIIa antibodies and that there are GP IIb/IIIa on HUVE.
- 一般社団法人 日本血栓止血学会の論文
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