Effect of platelet membrane lipid fraction on actin polymerization.
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概要
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Effects of membrane fraction of human platelets on polymerization of actin have been examined. Freshly prepared membrane fraction inhibited the polymerization, whereas the membrane fraction which was once frozen after preparing fresh membrane fraction accelerated the polymerization. Liposomes which were composed of lipids obtained from the platelet membrane showed higher acceleration of the polymerization. When the membrane fraction was pretreated with thrombin or phospholipase A2, acceleration of actin polymerization was observed by the fraction. Pretreatment with phospholipase C, however, showed no effect on the polymerization. Liposomes formed by PtdIns (4, 5) P2 showed highest acceleration. From these findings we concluded that not only changes in free calcium ion level, but also some conformational change or electric charge of the membrane would be responsible to the induction of actin polymerization.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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