Studies on hemostatic findings and effect of small dose of aspirin administration with or without dilazep in patients with prosthetic heart valves.
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Platelet survival time by MDA method, platelet functions and some coagulation parameters were examined in 45 patients with prosthetic valves. These parameters were also measured after administration of aspirin (40mg/day) with or without dilazep (300mg/day) for 4 weeks, in 22 of these 45 patients. All patients except one were under warfarin treatment, and the mean value of thrombo-test was 20.9% (8.5-85%).The following results were obtained;1) Platelet survival time was decreased in 26 (57.8%) of these patients.2) After administration of aspirin with or without dilazep, platelet aggregability was suppressed significantly.3) Platelet survival time was prolonged after 4 weeks of administration of aspirin with dilazep, as compared with that obtained before treatment.These results suggest that small dose of aspirin with dilazep may prevent thrombo-embolic complications in these patients with prosthetic heart valves.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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