Heat-treatment of factor VIII concentrate. Preservation of F VIII activity and virus inactivation effect.:preservation of F VIII activity and virus inactivation effect
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Heat-treatment of lyophilized factor VIII concentrate at 60°C resulted in a slight decrease in the factor VIII procoagulant activity (VIIIC), whereas a great decrease in the VIII C activity was detected at more than 70°C. A complete inactivation of viruses such as Entero, Orthomyxo, Paramyxo, Toga, Herpes and Adeno viruses in lyophilized factor VIII concentrate was attained by heating at 60-65°C for 5-30 hours. Optimal heating condition as to inactivation of hepatitis virus, where temperature and incubation time were at 65°C and for 96 hours, respectively, was chosen on the basis of the experiments using parvo virus. Effectiveness of heat-treatment (65°C, 96 hours in lyophilized state) in the inactivation of non-A, non-B agent appeared to be confirmed in chimpanzee test.
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