Membrane phospholipid turnover and cAMP in human platelets.
スポンサーリンク
概要
- 論文の詳細を見る
The influence of forskolin, an adenylate cyclase activator, and of dibutyryl cyclic AMP (Bt2cAMP) on the thrombin-induced [3H] glycerol incorporation into glycerolipids was investigated in human platelets. It was found that preincubation with 2.5mM of Bt2cAMP produced 2-4-fold increase in thrombin-induced incorporation into phospholipids compared to platelets activated by thrombin alone. Pretreatment with forskolin, which increased cellular cAMP content, also resulted in an increase in thrombin-stimulated [3H] glycerol incorporation into phospholipids. These findings demonstrate that a rise in platelet cAMP can accentuate thrombin-induced de novo synthesis of phospholipids from [3H] glycerol. Since the content of cellular cAMP was correlated with their ability to inhibit platelet activation monitored by serotonin release, it seems likely that glycerolipids, in particular phospholipids, biosynthesis is somehow involved in controlling platelet activation by thrombin.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
- 日本人のＡＤＡＭＴＳ１３
- Infection of specific strains of Streptococcus mutans exacerbated intracerebral hemorrhage
- Transcriptional regulation of megakaryopoiesis and thrombopoiesis
- 新規血小板活性化受容体ＣＬＥＣ－２ その発見から今後の展望まで:その発見から今後の展望まで
- １．臨床血栓止血学オーバービュー