:Effects of Daunorubicin and Doxorubicin on platelet adhesiveness and morphology of adherent platelets
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概要
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Some antineoplastic agents inhibit platelet aggregation. In this study, the effects of Daunorubicin (DNR) and Doxorubicin (DXR) on platelet adhesiveness were investigated by the glass bead column method, a method of adhesiveness to Collagen-Sepharose and Baumgartner's method. And molphology of these adherent platelets were observed by electron microscope.Also, the influence of the combination of antineoplastic agents and Dilazep (DZP), or dl-α-Tocopherol (V. E) was investigated Baumgartner's method.In the glass bead column method, platelet retention rate was significantly reduced with DNR (10-4 moles f. c) and DXR (10-4 moles f, c). Scanning electron microscopy revealed that adherent platelets on the glass surface extended pseudopds and were spread out. However, the number of aggregated platelets was reduced. In the method of adhesiveness to Collagen-Sepharose, no change in morphology of adherent platelets to collagen fibers was seen as compared with the controls. The effect of DNR or DXR in this method was not significant. It was demonstrated that platelet adhesion and aggregation are inhibited by DNR and DXR, using Baumgartner's method. They inhibited spreading out of adherent platelets at the subendothelial surface, and DNR also inhibited extending pseudopods. By transmission electronmicroscopic findings, adherent platelets at the subendothelial surface of rabbit aorta were observed to retain the granules and the ring of microtubules in the marginal zone.The effect of combination of antineoplastic agents with DZP or V. E was not significant.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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