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In 22 untreated male patients with essential hypertension (HT) and 6 male normotensives (NT), platelet function and erythrocyte membrane sodium transport (ouabain sensitive rate constant: K, ouabain sensitive sodium efflux: M) were studied after low (NaCl 5g/day) and high (25g/day) sodium diet individually for 7 days.In HT, 24 hour-average of mean blood pressure was elevated (5mmHg, p<0.005) after high sodium diet, but not in NT.In HT, platelet aggregation induced by ADP and epinephrine increased significantly after high sodium diet compared with after low sodium diet (Fig. 1). In contrast, plasma levels of beta-thromboglobulin and platelet factor 4 were significantly higher after low sodium diet than after high sodium diet (Fig. 2). This may be due to the elevated blood viscosity (p<0.005 at any shear rate) because of increased hematocrit and serum protein (p<0.001) after low sodium diet than after high sodium diet.In NT, no sgnificant change was obsreved in platelet function.In HT, K and M were reduced (from 0.281±0.067 to 0.265±0.064/h, from 3.238±0.571 to 3.071±0.540 mEq/1 cell h, p<0.02) after high sodium diet compared with after low sodium diet. But there was no significant correlation between the changes in platelet function and the reduction in erythrocyte membrane sodium transport.
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