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This study was conducted to elucidate the influence of the diabetic status and hemostatic factors which might participate in the develoment of microangiopathy (retinopathy, nephropathy and neuropathy).The results obtained from 52 patients with diabetes (52±12 years of age, male 18, female 34) were as follows:The development of the microangiopathy, observed in thirty seven among fifty two patients, correlated well with the suffering duration (1-25 years) of diabetes mellitus (DM). Increased level of fibrinogen and von Willebrand factor, hyperfunction of platelet demonstrated by ADP-induced aggregation as well as increase in number, decreased AT III, α2-PI and plasminogen level were observed with thier higher grades as their severity of grade of microangiopathy advanced. In DM of poor controlled groups (28 cases; FBS>120mg/dl, 2hrs blood sugar level after a meal>200mg/dl), platelet counts, fibrinogen and von Willebrand factor level were elevated and ADP-induced platelet aggregation was more hyperactive significantly than that of good controlled groups (22 cases; FBS=120mg/dl, 2hr blood sugar level after a meal≤200mg/dl, for at least on month). These findings were more remarkable in brittle type of DM. These results support the hypercoagulable state exist in DM and suggested that these factors in plasma and platelets promote the injury of the vessel wall directly or indirectly to induce the miroangiopathy.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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