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PGI2 and TXA2 synthesis in glomeruli isolated from rat kidney was investigated and following results were obtained. PGI2 and TXA2 were measured by RIA kit (New England Nuclear). TXB2 production was increased by addition of arachidonic acid, but synthesis of 6-keto-PGF1α was slightly increased. The recovery of added TXB2 in presence of indomethacin was almost 100%. On the contrary, the recovery of added 6-keto-PGF1 was remarkably reduced. From these results it was concluded that 6-keto-PGF1α might be farther metabolized in glomeruli. TXA2 synthesis was inhibited by addition with aspirin (ASA), Indomethacin and OKY 1581. Dipyridamole slightly inhibited TXA2 production in vitro and in vivo, and increased PGI2 production in vivo, while Trapidil inhibited TXA2 production in vivo and more remarkably increased PGI2 production in vivo.
- 一般社団法人 日本血栓止血学会の論文
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