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The contribution of vasoactive substances to secretion of PGI2 from coronary vessel wall was examined in the isolated perfused dog hearts by a modification of the method of Langendorff.Infusion of bradykinin (5μM) or thrombin (25u/ml) into the heart for 30sec resulted in transient release of an inhibitor of platelet aggregation. The inhibitor was reported to be PGI2 (Ref. 1, 2). The inhibitor was not observed when acetylcholine, noradrenalin, isoproterenol (25μM, respectively), ATP (10μM), adenosine (5μM), angiotensin II (1μM), histamine (25μM) or serotonin (1μM) was infused.Bradykinin (5×10-9M to 5×10-6M) and thrombin (10-9M to 10-7M) caused dose-dependent release of PGI2 which was assayed by a radioimmunoassay for 6 keto PGF1α.
- 一般社団法人 日本血栓止血学会の論文
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