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The effects of treadmill exercise stress (up to 85% of the predicted maximum heart rate) on platelet functions and coagulating activities were studied in healthy males. Blood sampling for the measurements were performed from the antecubital vein at rest, 3, 6, 9 and 12 minutes during exercise, and 6 and 30 minutes after exercise.No significant changes were noticed in platelet sensitivities and maximum and 3 minute percent platelet aggregation to 4 concentrations of ADP between at rest, during exercise and after exercise. Platelet counts increased during and after exercise in platelet rich plasma without significant changes of platelet counts in whole blood. Plasma thromboxane B2 levels showed a tendency to increase, while plasma 6-keto-prostaglandin F1α levels to decrease. Plasma epinephrine levels showed a tendency to increase and norepinephrine levels increased during and after exercise. Among coagulating factors, factor VIII activities and fibrinogen levels increased without any significant change in activities of factors IX, XI and XII. Antithrombin III activities also increased during and after exercise. In spite of significant changes in several coagulating factors, prothrombin time and partial thromboplastin time were not influenced by exercise.In conclusion, moderate exercise produced a significant elevation of factor VIII, fibrinogen, antithrombin III and catecholamine without affecting the hemostatic balance.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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