:in vitro studies on the dengue virus-platelet interaction
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Changes of platelet counts by dengue virus (DV)-platelet interaction were studied in vitro with the aim to investigate a mechanism of how virus causes prominent thrombocytopenia characteristically seen in some virus disease, such as dengue hemorrhagic fever. The results obtained showed (1) that human platelets bound DV-antigen without immune-mediated reaction, (2) that decrease of platelet counts was more markedly demonstrated by the binding of anti-DV antibody on the DV-antigen associated with platelets than by the binding of DV-antigen·anti-DV-antibody complex on the platelets, and (3) that an interaction of platelet with DV-infected endothelial cell induced the decrease of platelet counts.
- 一般社団法人 日本血栓止血学会の論文
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