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The regulation mechanism of fibrinogen synthesis is unclear. Thrombin, free fatty acids, ACTH, FgDP were reported as stimulators of fibrinogen synthesis. This experiment was done to examine the existence of humoral stimulating factors in DIC serum. In dogs, after continuous infusion of tissue thromboplastin (Lyoplastin) 12.5mg/kg for 3hrs, platelet counts, antiplasmin, fibrinogen decreased to nearly 30%, 35%, 0% and FPA, FDP increased to 10ng/ml, 660μg/ml respectively. After cessation of administration of Lyoplastin, fibrinogen increased rapidly and returned to the value of preinjection at 3 days after. So, these dogs were used as acute DIC model. Serum of these dogs was sampled at this recovery phase of fibrinogen (6, 24, 48, 72hrs) and treated with bentonite to absorb FDP. 3ml of these sera were administered to rabbits and 75Se-methionine (75Se-M) 20μCi was injected 5hrs after. The effects of DIC dog serum on fibrinogen synthesis in rabbits were evaluated by calculating the incorporated 75Se-M into newly synthesized fibrinogen and by circulating fibrinogen concentration. Although the statistical significance was not obtained, the existence of humoral stimulating factors on fibrinogen synthesis in rabbits was suggested by injectien of DIC induced dog serum at 72hrs after Lyoplastin infusion.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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