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We studied 152 apparently healthy newborns below 30 days of age on crossed immunoelectrophoresis of prothrombin using capillary blood samples, in order to find out the frequency of mild vitamin K deficiency in healthy infants. About 70% of the newborns at 0 to 3 days of age, 47% of the newborns at 4 to 5 days of age and 28.6% of the newborns at 6 to 9 days of age had PIVKA-II on crossed immunoelectrophoresis.Sixty six infants at one month of age included 28 breast fed infants and 38 either mixed or bottle fed infants. About 14% of these infants had a small amount of PIVKA-II. Although the frequency of mild vitamin K deficiency was very high at birth and quickly decreased to 28.6% by 6 to 9 days after birth, about 14% of apparently healthy infants at one month of age remained mildly deficient from vitamin K, no matter what the type of feeding may be. Through a large scale screening test using Normotest, 16 infants at one month of age were picked up for their value of less than 50% of normal. Among these 16 infants, 87.6% of them were demonstrated to have PIVKA-II and sigificantly larger amount of PIVKA-II than in one month old infants in group D. There was negative correlation between the amount of PIVKA-II and the value of Normotest in these infants.In conclusion, 70% of newborns at birth are deficient from vitamin K and this deficient state is alleviated gradually and spontaneously with age. However, about 14% of one month old infants are still mildly deficient from vitamin K, no matter what the type of feeding may be.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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