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Recently, the vascular injury have been investigated as the most important complications of Diabetes Mellitus (DM). We studied on the correlation between Kallikrein system and haemostasis in DM. The results are as follows.1) Platelet β-thromboglobulin (β-TG) levels were 31.0±18.0ng/ml in normal subjects and 87.0±61.8ng/ml in DM. In the group with retinopathy β-TG level was 65.8±41.5ng/ml and it was 97.5±53.5ng/ml in the group with nephropathy.2) There was a positive correlation cetween β-TG and platelet factor 4 levels in DM. (r=0.81)3) Prekallikrein (PK) level was 94.8±6.0% in normal subjects and 83.9±38.0% in DM. In DM group without complications, PK level was 111.8±24.9%.It was 56.6±34.3% in the group with retinopathy and 76.4±26.3% in the group with nephropathy. In PK level significant decrease was recognized in DM with complications.4) Factor XII level increased in DM. There was significant correlation between F-XII and PK levels in DM. (r=0.74)5) There was a positive correlation between β-TG and PK levels in DM.6) Plasminogen level decreased in DM. There was a correlation between plasminogen and PK levels. (r=0.3)7) α2-plasmin inhibitor level increased in DM. There was also a correlation between α2-Pl and PK levels. (r=0.36)8) In cholorpropamide alcohol flashing test, skin temperature showed a gradual elevation. But, in comparison with normal subjects group, it was relatively low in DM group. Platelet aggregation and PK levels gradually decreased in normal subjects. But, in DM with retinopathy groups they were widely variable. The changes of conjuctive capillaries by alcohol test was poor in vascular complication groups. The changes of PK levels suggested Kallikrein formation and Kallikrein converted Kininogen to Kinin. Kinin had vasoactive effect and Insulin like activity.It is concluded that the changes of these factors levels in vascular complications with DM, and showed thrombotic tendency and disturbances of circulation and glucose metabolism. These haemostatic factors are related to the progress and prognosis of vascular complication in DM.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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