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Platelet aggregation, plasma β-thromboglobulin (β-TG) and platelet ATP and ADP contents were examined in 20 patients with chronic glomerulonephritis (CGN) and 10 normal controls. Contents of platelet ATP and ADP which were extracted with ethanol were measured by Holmsen's firefly luciferase method. The mean values of platelet aggregation and plasma β-TG in the patients were significantly higher compared with those of normal controls. The mean platelet ATP content in the patients was 7.10±0.20 (SE)μ moles/1011 platelets, significantly (p<0.05) lower than that of normal controls (7.87±0.36μ moles/1011 platelets). The mean platelet ADP content was 3.34±0.18μ moles/1011 platelets in the patients. This value was lower than that of normal controls (3.59±0.22μ moles/1011 platelets) although this did not reach significance. The mean platelet ATP content was significantly (p<0.05) lower in patients with hypoalbuminemia than in those without it.The results suggest that platelet aggregation and release reaction were increased in patients with CGN. Decreased adenine nucleotides in platelets may be related to the increased platelet energy metabolism in addition to the decreased storage pool in the patients.
- 一般社団法人 日本血栓止血学会の論文
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