:Involvement of deacylation-reacylation
スポンサーリンク
概要
- 論文の詳細を見る
The positional distribution of fatty acids in phospholipids was analyzed for human platelets activated by thrombin. At 30 sec after thrombin-activation, when the content of phosphatidylinositol (PI) fell by 40%, the 2-position of PI underwent a significant decrease in arachidonate (77.6%→61.5%) with a compensating increase in oleate and stearate. However, following PI resynthesis (10min after thrombin-activation), its positional distribution tended to revert to that of non-activated platelets. No significant change was detected in the fatty acyl positioning in other phospholipids. In addition, evidence is presented that human platelet lysates acylate 1-acyl-sn-lycero-3-phosphorylinositol and the acylation rate for arachidonate was 2.5 times higher than for any other unsaturated fatty acids tested. These findings indicate that thrombin-induced alteration in fatty acid paring of PI is subsequently rearranged by the deacylation-reacylation after PI resynthesis.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
- 日本人のＡＤＡＭＴＳ１３
- Infection of specific strains of Streptococcus mutans exacerbated intracerebral hemorrhage
- Transcriptional regulation of megakaryopoiesis and thrombopoiesis
- 新規血小板活性化受容体ＣＬＥＣ－２ その発見から今後の展望まで:その発見から今後の展望まで
- １．臨床血栓止血学オーバービュー