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1) Types of epinephrine-induced aggregation in chronic myeloproliferative disorders were classified into three types according to a concentration of epinephrine added in the PRP. The first type of aggregation curve revealed normal responsiveness in response to a usual concentration of l-epinephrine (5μM). The second type revealed defective or decreased responsiveness to 5μM l-epinephrine, but a normal responsiveness appeared at a higher concentration of l-epinephrine. The third type showed no responsiveness to any concentration of l-epinephrine (10μM, 100M and 1mM). We called above those types of aggregation curves Type I, Type II and Type III, respectively.2) 3H-DHEC (3H-Dihydroergocryptine) binding assay in washed intact platelets was studied according to the method of Newman et al. with a minor modification. Platelets in Type I revealed normal values in 3H-DHEC binding sites. In Type II, 3H-DHEC binding sites were slightly fewer than in normal controls or reduced to half numbers of normal controls. In Type III, 3H-DHEC binding sites revealed half numbers of normal controls.3) The cAMP level in the PRP in Type I showed normal enhancement by PGE1 and a sufficient decrease in response to epinephrine. In Type III, the cAMP level in the PRP demonstrated only 10 to 20% of normal enhancement by PGE1 and no responsiveness to epinephrine. Whereas, in Type II, various attitudes were observed in response to PGE1 and epinephrine.4) Platelets in Type III revealed sufficient potentiation of ADP aggregation due to a low-dose epinephrine. Therefore, the mechanism of epinephrine aggregation might be different from that of potentiation of ADP aggregation due to a low-dose epinephrine.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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