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When disseminated intravascular coagulation (DIC) persists, heparin becomes inefficacious at times, since activated factors impaired the inhibitory capacity of antithrombin III, while reacting in the presence of heparin. From the point of view, the application of serine proteinase inhibitor has been proposed for the prevention and treatment of DIC. In the experiment, radioactive fibrinogen was given to the rats and while DIC was induced by infusion of thrombin or tissue thromboplastin, deposition of the radioactive fibrin to the kidneys were directly detected by a γ-counter and monitored continuously. Cocomittant with platelet count, whole blood radioactivity and organs radioactivity, the effect of aprotinin on experimental DIC was investigated in comparison with that of FOY. The continuous administration of 120μmol of FOY/kg/h effectively inhibits the microthrombi formation induced by thrombin or tissue thromboplastin. Aprotinin failed even at the dose of 50, 000u/kg/h. On the other hand, as for fibrinolysis, FOY at the above dose not show any alteration on the naturally occered secondary fibrinolysis when thrombin-induced microthrombi were firstly provoked. Aprotinin was potent in antiplasmin that at 5, 000u/kg/h or 2, 000u/kg the fibrinolynosis was completely blocked. From these results, it may be concluded that without combination with other anticoagulant agents, aprotinin alone in management the patient of DIC was underserved.
- 一般社団法人 日本血栓止血学会の論文
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