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The intimal damage was induced by the injection of saturated saline solution into the femoral artery of rabbit. The endothelium was disappeared on 2 days after the irritation. The subintimal hyperplasia was shown on 9 days after the irritation. In the experimental group, the artery was cut on 2 days after the irritation and was anastomosed immediately under the operative-microscope. In the control group, the artery was anastomosed without the irritation. Anticoagulants were not used systemically, but the arterial lumina was washed with the heparinized saline solution.All arteries in both groups were patent on 7 days after anastomoses, but many of them in the experimental group were stenosed due to thrombus.Histologically, subintimal hyperplasia of the artery was shown in the experimental group, but it was not in the control group. It was thought that the blood flow prohibits the anastomosis from occlusion even in the region with thrombus formation.
- 一般社団法人 日本血栓止血学会の論文
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