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In order to analyze the relationship between autoimmunological phenomena and coagulofibrinolytic reactions in systemic lupus erythematosus (SLE), we studied 20 patients with SLE, 9 of whom were active (CH50<30U/ml), 11 were inactive (CH50>30U/ml), about thrombotic episodes and coagulofibrinolytic functions. The results obtained were as follows:1) 5 thrombotic episodes were complicated in active SLE, and 1 in inactive SLE.2) In active SLE β-thromboglobulin level was increased, fibrinogen turnover was increased, and levels of plasminogen and antithrombin-III were low as compared with those in inactive SLE.3) CH50 and level of antithrombin-III showed a positive correlation (r=0.77) and a clear parallelism in a case of SLE.It was postulated that with the progress of disease activity in SLE it was inclined toward hypercoagulable state, and so thrombotic tendency was accelerated.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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