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Platelet factor 3 (PF3) activity was determined using chromogenic substrate S-2238 (Kabi).During aggregation induced by collagen (20μg/ml) PF3 activity up to 10% was appeared in the supernatant concomitant with LDH activity. No close relation was observed between PF3 activity and aggregation rate or the amount of released platelet specific proteins (Fig. 1). PF3 activity in the supernatant increased up to 32% during A23187 (5-10mM) induced aggregation. PF3 activity was always higher than LDH activity which derived from lysed platelets. PF3 activity was appeared in the supernatant prior to release of alpha-granule contents (Fig. 2). During primary or secondary aggregation induced by ADP no PF3 activity was observed in the supernatant (Fig. 3).These results suggest that PF3 activity appeared in the supernatant during aggregation was derived by various mechanism, namely platelet lysis and/or mobilization from the membrane. The possibility that PF3 was released from alph-granules is less likely.
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